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ea0016p207 | Diabetes and cardiovascular diseases | ECE2008

Elevated plasma fatty acid levels are associated with myocardial triglyceride accumulation and diastolic dysfunction in type 2 diabetes mellitus which can be reversed by acipimox

Smit Joahnnes , Hammer Sebastiaan , van der Meer Rutger , de Roos Albert , Lamb Hildo , Romijn Johannes

Background: Although it has been conceived that type 2 diabetes mellitus (DM2) is associated with increased myocardial triglyceride (TG) accumulation, it is unknown whether this can be influenced by modifying plasma non-esterified fatty acids (NEFA) levels. We therefore determined in uncomplicated DM2 whether modifications in plasma NEFA influence myocardial TG content and myocardial function.Research design and methods: Myocardial TG content and left ve...

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ea0056oc6.5 | Genetic and environmental determinants of obesity and insulin resistance | ECE2018

Associations of different body fat deposits with serum 25-hydroxyvitamin D concentrations

Rafiq Rachida , Walschot Floor , Lips Paul , Lamb Hildo , de Roos Albert , Rosendaal Frits , den Heijer Martin , de Jongh Renate , de Mutsert Renee

Introduction: Overall and abdominal obesity are both well-established risk factors of vitamin D deficiency. However, it is unclear which fat depot is most strongly related to serum 25-hydroxyvitamin D (25(OH)D) concentrations.Objective: This study aims to distinguish specific contributions of total body fat, abdominal subcutaneous adipose tissue (aSAT), visceral adipose tissue (VAT) and hepatic fat on 25(OH)D concentrations.Methods...

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Endocrine Abstracts

Elevated plasma fatty acid levels are associated with myocardial triglyceride accumulation and diastolic dysfunction in type 2 diabetes mellitus which can be reversed by acipimox

Associations of different body fat deposits with serum 25-hydroxyvitamin D concentrations

BiosciAbstracts